Peyronie's Disease (fibrous cavernositis)
By Dr. Theodore R. Herazy, Peyronie's Disease Institute

Peyronie's disease is a health problem involving the male reproductive organ of unknown origin. It follows an extremely variable course, making the condition extremely difficult to both study and treat. Everything about this condition is variable except the presence of one or more fibrous scar nodules, located under the skin along the shaft of the penis. The scar of Peyronie's disease (PD) causes the penis to curve or bend when erect, prompting the nickname "the bent penis disease". Often the abnormal curvature is so severe - and painful for both partners - that it results in erectile dysfunction and impotence. 

This terrible condition is more common than most people realize, occurring in an estimated 3 out of 100 men over the age of 40, throughout the world. The fundamental problem of PD is the scar that results in pain, deformity and loss of sexual function. 

Peyronie's disease remains one of the most perplexing and difficult problems in urology to treat; it has been called "the doctor's nightmare". Currently there is no known treatment for the PD scar, because every treatment has met with only sporadic and limited success. Men with PD are often told there is no proven or accepted treatment for their condition, and are told to learn to live with their limitation and pain. However, the most promising new therapy currently being investigated with increasing reports of success are the enzymes nattokinase and serrapeptase. 

It is important to understand that an enzyme is a protein molecule that either starts or speeds up a chemical process without being used up or consumed in the process that it affects. Enzymes start or continue many thousands of complex chemical reactions that occur continuously throughout the body. They have been called "the fountain of life" because without them life could not exist. Over 3,000 protein-based enzymes start or speed up over 7,000 vital reactions in the body. Most enzymes are very specific in what they do; those enzymes of interest to PD - nattokinase, serrapeptase and bromelain - supply growing evidence they have great potential to reduce the fibrous material of the PD scar.

The idea behind taking enzymes to treat PD is to use a natural process of breaking up and eliminating abnormal fibrous tissue and foreign proteins. That's what these enzymes appear to be designed to do - break up the bad stuff that should not be there, like the nasty PD scar. The body has a wisdom that detects the presence of these abnormal cells and tissue elements, and removes them whenever and wherever possible - using enzymes to treat PD takes advantage of that wisdom. You take advantage of the latest and the best of recent science when you use enzyme therapy to support and stimulate the body's defense system. 

The primary enzymes in NEPRINOL® are nattokinase and serrapeptase, accompanied by CoEnzyme Q10 and other enhancing nutritional elements, act to break down foreign fibrous tissue wherever it is detected in the body - such as in the fibrous nodule of scar tissue that is the basic problem in Peyronie's disease. There has not yet been formal research for the clinical use of nattokinase and serrapeptase in PD. However, there are abundant favorable research reports with similar health problems that also have a fibrous tissue component, such as: uterine fibroids, fibrocystic breast disease, pulmonary fibrosis, hardening of the arteries (atherosclerosis), carpal tunnel syndrome and rheumatoid arthritis. These conditions all present similar tissue pathology, and this is often sufficient clinical justification to use medical treatment in related conditions. 

The beneficial effect of using NEPRINOL®, which contains an exceptionally concentrated dose of nattokinase and serrapeptase along with synergistic compounds, is that it promptly begins to break down the abnormal PD fibrous scar tissue, and allows it to be gently removed from the body as any other cellular debris. However, added benefits of NEPRINOL® to the PD sufferer is that it also reduces inflammation around the scar region, improves local and systemic circulation, and improves the ability of the immune system to heal the scar area.

While reports of success have been received after the use of nattokinase and serrapeptase to remove the fibrous tissue that makes up the PD scar, progress is slow and requires prolonged and consistent treatment. Early reports are encouraging, and this is great news for any man with PD considering how difficult this condition is to treat with standard medical care. The use of enzyme therapy is an important part of a larger treatment program that is advocated by the Peyronie's Disease Institute. 

For the first time, men with PD using NEPRINOL® have some reason to be encouraged and have hope that their problem has a safe, reasonable and effective therapy that is showing encouraging results in this most difficult to treat condition.

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